All cells of the immune system are created within
the bone marrow. Our bone marrow tissue is the school of the immune
system. Here immune cells learn to communicate with bone cells and
thereby regulate bone formation and bone resporption.
precise and coordinated interplay of different messenger substances
regulate the balance of bone forming osteoblasts and bone resorbing
osteoclasts. If this mechanism is disturbed, so that the number of
osteoclasts are increased, diseases such as osteoporosis emerge. In
addition, this also changes the functions of the immune system.
Within 20 different projects, scientist of the IMMUNOBONE consortium
investigate the interplay between inflammatory cells, messenger
substances, bone forming and bone resorbing cells. During the first
three project years (2010 - 2013) scientists discovered and
contributed to a better understanding of different communication
channels between cells of the bone and immune systems.
the immune system damages bones and joints or how the skeletal
system leads the immune system to an imbalance is yet to be