Priority Programm SPP 1468 “Osteoimmunology IMMUNOBONE – A Program to Unravel the Mutual Interactions between the Immune System and Bone”

An interdisciplinary cooperative project to investigate communication channels between the immune and skeletalsystem

                 Herausgeber: Uni-Klinikum Erlangen/Kommunikation, 91012 Erlangen

All cells of the immune system are created within the bone marrow. Our bone marrow tissue is the school of the immune system. Here immune cells learn to communicate with bone cells and thereby regulate bone formation and bone resporption.

A precise and coordinated interplay of different messenger substances regulate the balance of bone forming osteoblasts and bone resorbing osteoclasts. If this mechanism is disturbed, so that the number of osteoclasts are increased, diseases such as osteoporosis emerge. In addition, this also changes the functions of the immune system.

Within 20 different projects, scientist of the IMMUNOBONE consortium investigate the interplay between inflammatory cells, messenger substances, bone forming and bone resorbing cells. During the first three project years (2010 - 2013) scientists discovered and contributed to a better understanding of different communication channels between cells of the bone and immune systems.

Why the immune system damages bones and joints or how the skeletal system leads the immune system to an imbalance is yet to be completely understood.



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